Cytokines in CAR T Cell–Associated Neurotoxicity
نویسندگان
چکیده
منابع مشابه
Cytotoxic T-Cell Markers and Cytokines in Human Papillomavirus 16
Background and Aim: Cervical cancer is the fourth main cause of mortality among women, and annually about half a million new cases are detected in developed countries. Based on oncological studies, human papillomavirus (HPV) is classified into two categories: high-risk type and low-risk type, and most cases are related to the high-risk type of human papillomavirus. HPV 16 and 18 are among the m...
متن کاملCAR T- cellها: درمانی هدف‌مند در سرطان
سابقه و هدف: با توسعه و پیشرفت روزافزون در زمینة ایمنی‌درمانی تومورها، امروزه توجه خاصی به درمان‌های ایمنی انواع سرطان‌ها معطوف شده است. درمان‌های بر پایة گیرنده‌های کایمری آنتی‌ژن‌ها (CARs)، یکی از انواع درمان‌های مبتنی بر سلول‌های Tی تغییریافته به‌شمار می‌رود که به‌صورت هدف‌مند تنها روی سلول‌های توموری فرد و نه سلول‌های طبیعی اثر می‌گذارد. مواد و روش‌ها: پژوهش‌ها در دهه‌های اخیر حاکی از این ا...
متن کاملDesign and development of CAR-T cells for cancer therapy
Introduction: Today, treatment with CAR-T cells is accepted as an effective treatment for blood malignancies. CAR-T cells are autologous T cells that are engineered by gene transfer techniques to express a chimeric antigen receptor (CAR). Despite the promising results and the approval of six CAR-T cell products; these products have not yet been approved for solid tumors. In addition, the high c...
متن کاملNew development in CAR-T cell therapy
Chimeric antigen receptor (CAR)-engineered T cells (CAR-T cells) have yielded unprecedented efficacy in B cell malignancies, most remarkably in anti-CD19 CAR-T cells for B cell acute lymphoblastic leukemia (B-ALL) with up to a 90% complete remission rate. However, tumor antigen escape has emerged as a main challenge for the long-term disease control of this promising immunotherapy in B cell mal...
متن کاملNext frontiers in CAR T-cell therapy
Chimeric antigen receptor (CAR) T-cell therapy is entering a new era, transitioning from an experimental approach being tested in a handful of centers to a more mainstream and broadly investigated therapeutic platform with significant efforts directed towards commercial translation. CARs are synthetic receptors engineered and transduced into T cells to redirect T-cell cytotoxicity by recognitio...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Frontiers in Immunology
سال: 2020
ISSN: 1664-3224
DOI: 10.3389/fimmu.2020.577027